Safety issues concerning anti-hCG vaccines.
نویسنده
چکیده
منابع مشابه
DNA Vaccines: Regulatory Considerations and Safety Aspects.
DNA vaccines have great potential as preventive or therapeutic vaccines against viral, bacterial, or parasitic diseases as well as cancer, and may also be used as gene therapy products. Although many human and veterinary DNA vaccines have been investigated in laboratory trials, only four of these have been approved for commercial use. In this paper an overview of the regulatory requirements for...
متن کاملActive specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival.
PURPOSE Human chorionic gonadotropin (hCG) is produced by colorectalcancers and may play a role in its progression. The clinical and immunological effects of a synthetic vaccine targeting beta-hCG composed of the COOH terminal peptide of beta-hCG (CTP37) conjugated to diphtheria toxoid (DT) was investigated in patients with metastatic colorectal cancer. EXPERIMENTAL DESIGN Seventy-seven patie...
متن کاملRecent advances in contraceptive vaccine development: a mini-review.
Contraceptive vaccines (CV) may provide viable and valuable alternatives to the presently available methods of contraception. The molecules that are being explored for CV development either target gamete production [luteinizing hormone-releasing hormone (LHRH)/GnRH, FSH], gamete function [sperm antigens and oocyte zona pellucida (ZP)], and gamete outcome (HCG). CV targeting gamete production ha...
متن کاملRecombination plasmid carrying hcg and survivin combination IL-12 generates specific immune responses and anti-tumor effects in a murine breast carcinoma model
The effectiveness of DNA vaccination alone is limited, because it often generates only a weak cellular immune response; therefore, the complementary use of adjuvants may be required to improve vaccine potency and enhance its immune protective effects. The present study aimed to determine the effect of recombinant DNA vaccine-based human hcg and survivin on the development of breast carcinoma in...
متن کاملFertility regulating and immunotherapeutic vaccines reaching human trials stage.
The progress and current status of vaccines which induce antibodies against human chorionic gonadotrophin (HCG) and luteinizing hormone-releasing hormone (LHRH) are reviewed. Three vaccines devised against HCG have undergone phase I clinical trials documenting their safety, and reversibility. One of these, the heterospecies dimer (HSD)-HCG vaccine has also completed phase II efficacy trials in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Linacre quarterly
دوره 63 3 شماره
صفحات -
تاریخ انتشار 1996